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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K6
All Species:
21.52
Human Site:
Y305
Identified Species:
39.44
UniProt:
P52564
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52564
NP_002749.2
334
37492
Y305
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
L352
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851023
334
37590
Y305
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
Cat
Felis silvestris
Mouse
Mus musculus
P70236
334
37414
Y305
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
Rat
Rattus norvegicus
Q4KSH7
419
47517
K370
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
Y321
N
P
A
E
R
M
S
Y
L
E
L
M
E
H
P
Chicken
Gallus gallus
Q90891
398
44059
L358
N
P
A
E
R
A
D
L
K
M
L
M
N
H
T
Frog
Xenopus laevis
Q07192
446
50082
R402
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
Y332
N
S
T
E
R
P
T
Y
T
E
L
M
Q
H
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
Y298
E
Y
M
A
R
P
N
Y
E
Q
L
L
K
H
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
K320
K
D
R
R
H
R
P
K
Y
D
T
L
K
S
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
A321
D
P
N
S
R
S
S
A
K
E
L
M
E
H
P
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
Y614
I
P
E
R
R
P
T
Y
A
A
L
T
E
H
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32
N.A.
98.8
N.A.
97.9
38.6
N.A.
75.2
34.4
43.5
80.6
N.A.
58.6
N.A.
38.2
N.A.
Protein Similarity:
100
47.8
N.A.
99
N.A.
99
53.7
N.A.
85.5
51.5
56
85.8
N.A.
74.8
N.A.
56.2
N.A.
P-Site Identity:
100
40
N.A.
100
N.A.
100
0
N.A.
60
40
13.3
86.6
N.A.
33.3
N.A.
0
N.A.
P-Site Similarity:
100
46.6
N.A.
100
N.A.
100
13.3
N.A.
73.3
40
40
86.6
N.A.
53.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
24.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.1
36
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
24
8
0
16
0
8
8
8
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
16
0
8
0
0
16
0
0
8
0
0
0
0
0
% D
% Glu:
8
0
8
54
8
0
0
0
8
47
0
0
31
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
8
0
0
0
0
0
0
0
0
77
8
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
16
0
31
0
8
0
8
16
24
8
8
8
16
0
0
% K
% Leu:
8
0
0
0
0
0
0
16
8
0
77
24
8
8
8
% L
% Met:
0
0
8
0
0
8
0
0
0
8
0
62
0
0
0
% M
% Asn:
54
0
8
0
0
0
8
0
0
8
0
0
8
0
0
% N
% Pro:
0
39
0
0
0
47
16
0
31
0
0
0
0
0
54
% P
% Gln:
0
0
0
0
0
0
0
0
0
16
0
0
31
0
0
% Q
% Arg:
0
0
8
24
77
16
0
8
0
0
0
0
0
0
0
% R
% Ser:
0
31
0
8
0
16
16
0
0
0
0
0
0
8
8
% S
% Thr:
0
8
8
0
0
0
39
0
8
0
8
8
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
54
16
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _